The Irish opened the season 3-1, with their only loss coming at the hands of nationally ranked Auburn. Since then, Notre Dame has dropped two dual meets to conference opponents to bring its record to .500.
On Saturday, Louisville topped the Irish 188-112, winning 10 of the 16 events. For the first time this season, Notre Dame (3-3) failed to claim victory in either the one-meter or three-meter dives. Junior Jenny Chiang took second in both events.
Freshman Emma Reaney led the Irish effort, taking first in the 100- and 200-yard breaststroke and the 200-yard individual medley, while swimming on the first-place 400-yard freestyle relay team.
Senior Amy Prestinario won the 100-yard freestyle in 50.80, while sophomore Kelly Ryan clocked in at 1:51.05 to win the 200-yard freestyle, rounding out Notre Dame's first-place finishes.
Louisville (3-1), like Notre Dame, benefitted from the play of its freshmen. The Cardinals' rookie swimmers accounted for four victories at the meet.
The Irish will take a break from competition for the remainder of November before heading to the Ohio State Invitational in Columbus, Ohio. The three-day meet begins Dec. 2.